Long-term issues such as social healthcare costs, short-term issues such as the stable supply of vaccines and therapeutic agents, and advanced technological issues such as regenerative medicine, and personalized medicine. To tackle these issues, methodologies are required to rethink and redefine the ideal state of medicine and pharma. In this symposium, we will discuss the role of systems approaches for such reimagination, by learning from modeling, simulation, evaluation/optimization researches. In particular, this year's symposium will deepen the discussion on how to overcome the gap between time and space scales.